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You retain copyright to your thesis and may make it available on a personal website and pursue other sources of publication as well.Your graduate unit may require one or more bound paper copies of your thesis.Tags: Appendix In EssaySpeeches Essay Questions HscEugenics Canada EssayNested Case Controlled Study DesignEssay About Cosmetic SurgeryPenalty And Racial Disparities ThesisFinance Homework Help OnlineWomen'S Suffrage Thesis StatementsFuture Business PlansNot For Profit Business Plan Template
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Hb released from lysed erythrocytes is quickly captured by serum haptoglobin (Hp) and the complex is degraded in the liver where released iron is then recycled.
To date, the Iron Surface Determinant (Isd) system is the only heme utilization pathway identified in S. Isd B is the primary receptor at the cell surface that binds Hb to extract heme.
In the first part of my study, the molecular mechanism of heme transfer from Hb to Isd B was investigated using site-directed mutagenesis.
Residues in the heme-binding pocket were identified by inspection of a crystal structure of the complex of Isd B and Hb.
In the second part of my study, Hp was found to inhibit heme transfer from Hb to Isd B in a concentration-dependent manner and heme transfer was completely blocked when Hp was added to Hb above the binding stoichiometry determined by structural and solution studies.
Moreover, Hb mixed with excess Hp did not support growth of S. This study gained insight into the heme transfer mechanism between Hb and Isd B and revealed a novel role of Hp in blocking heme uptake by S. STAPHYLOCOCCUS AUREUS HEME ACQUISITION FROM HEMOGLOBIN by Jun Wen Li B.
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