The disease is mainly concentrated in tropical and subtropical regions, putting nearly a third of the human population, worldwide, at risk of infection .
Department of Biochemistry, University of Delhi, Institute of Home Economics, Hauz Khas, New Delhi 110016, India Received 14 March 2016; Revised ; Accepted 1 June 2016Academic Editor: Mario Clerici Copyright © 2016 Niyati Khetarpal and Ira Khanna.
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The approximate molecular weight (in k Da) of each protein has been indicated in braces.
It consists of a single open reading frame and two noncoding regions (NCRs) at the 5′ and 3′ ends.
The impact of its limited application to the public health system needs to be evaluated.
Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals.The viral RNA is translated as a single polyprotein consisting of structural (light brown-C, pr M, and E) and nonstructural (dark brown-NS1, 2A, 2B, 3, 4A, 4B, and 5) protein components.Symbols C, pr M, E, NS, and PM denote capsid protein, precursor membrane protein, envelope protein, nonstructural proteins, and plasma membrane, respectively.A dramatic worldwide expansion of the DENV has occurred due to rapid urbanization, increase in international travel, lack of effective mosquito control measures, and globalization .Though there is no approved drug, an update by Sanofi Pasteur reveals licensure of its vaccine in Mexico, Brazil, Philippines, and El Salvador .(2) Epidemiology.This single polyprotein then gets processed by viral (green arrow) and host (black arrow) proteases.The structural proteins (pr M and E) remain anchored on the luminal side of the ER membrane.Major functions of all the proteins are summarized in Table 1 [11, 12].A three-dimensional image reconstruction of mature dengue virus shows that it is ~50 nm in diameter and consists of an outer protein shell (E and M), a lipid bilayer, and a less characterized nucleocapsid core (C and RNA genome).Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden.It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes.